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The Right Way To Use Niacinamide and Vitamin C: Expert Recommendation

2 models holding a bottle of niacinamide and vitamin C serum

Table of Contents

Can you layer niacinamide and vitamin C? This question has sparked debates among many skincare enthusiasts and experts due to concerns about skin irritation, among other things.

In this post, our experts provide a clear answer on using these skincare products for maximum benefits. Let’s dive right in!

Key Takeaways: Can You Layer Niacinamide and Vitamin C

Our experts advise against combining both in the same routine, especially if the vitamin C serum is an Ethyl Ascorbic Acid derivative.

Niacinamide and vitamin C are staple ingredients in the skincare world due to their amazing benefits for the skin. Individually, they can work wonders.

Combined together, they can also provide a wealth of benefits for the skin such as hydrating and brightening the skin. However, this can be quite tricky.

However, not all formulations of vitamin C will pair well with niacinamide in the same routine. So, to safely layer both together and avoid, consider using a more stable derivative of vitamin C like L-ascorbic acid, and ascorbyl palmitate, among others.

Overall, when in doubt seek advice from a professional skincare expert.

Understanding Niacinamide and Vitamin C

Niacinamide and its Benefits

Niacinamide, also known as vitamin B3, is a powerhouse ingredient in skincare. It boasts a range of benefits, making it a must-have in your routine.

  • Firstly, niacinamide helps to regulate oil production, making it ideal for those with oily or acne-prone skin.
  • Additionally, it enhances the skin barrier, improving moisture retention and reducing transepidermal water loss.
  • Furthermore, niacinamide has anti-inflammatory properties, calming redness and irritation, making it suitable for sensitive skin types.

Overall, incorporating niacinamide into your skincare routine can result in a smoother, more even complexion with reduced signs of ageing.

Vitamin C and its Benefits

Vitamin C is a potent antioxidant. It offers a range of benefits that make it a holy grail in the skincare world.

  • Firstly, it helps to fade dark spots and hyperpigmentation, giving the skin a radiant glow.
  • Vitamin C also boosts collagen production, promoting firmer, more youthful-looking skin.
  • Furthermore, it protects the skin from environmental damage caused by free radicals, such as pollution and UV radiation.

Ultimately,  incorporating vitamin C into your skincare routine can help you achieve a more radiant look while defending your skin against premature ageing.

Lady holding a bottle of niacinamide serum

The Right Way To Use Niacinamide and Vitamin C In Your Skincare Routine: Expert Recommendation

Here’s how our experts recommend using this skincare duo in your routine.

Morning Routine

Step 1: Prep the Skin with Cleansing and Toning

Before diving into any skincare routine, it’s essential to start with a clean canvas. So, begin by cleansing your face with a gentle cleanser suitable for your skin type.

This step removes dirt, oil, and impurities, allowing the active ingredients in your serums to penetrate effectively.


Once your skin is clean, follow up with a toner to rebalance your skin’s pH levels. Toners also help remove any leftover residue from cleansing while preparing your skin to absorb the following products more efficiently.

Step 2: Apply Vitamin C Serum (AM only)

Using the dropper, dispense 2-3 drops of this serum directly onto your skin and gently massage it for your skin to absorb.

Focus on areas prone to hyperpigmentation or sun damage for optimal results.

Step 3: Allow Vitamin C to be Absorbed Properly


Always give your products a few minutes to sink into your skin before moving on to the next step. This allows the active ingredients to penetrate deeply and work their magic from within.

So, allow about 10–15 minutes for your skin to absorb the vitamin C serum before moving on to the next product.

Step 4: Maximise Your Results with a Moisturiser and Sunscreen


To seal in all the goodness from your serums and provide hydration, don’t forget to moisturise. Choose a moisturiser suitable for your skin type and apply it evenly over your face and neck.

This step helps maintain your skin’s moisture barrier and ensures it stays hydrated throughout the day.


Last but certainly not least, never skip sunscreen, especially in the mornings and when using vitamin C in your routine. Sunscreen protects your skin from harmful UV rays.

It also prevents premature ageing and helps maintain the results of your skincare routine.

Night Routine

Replace step 2 with niacinamide serum and leave out the sunscreen. 

Overall, by following these steps you can safely use niacinamide and vitamin C in a routine without any complications.

How to Layer Niacinamide and Vitamin C for Sensitive Skin: Alternating Days Method

For individuals with sensitive skin, the simultaneous use of niacinamide and vitamin C can sometimes lead to irritation or redness. To minimise the risk of adverse reactions, consider alternating days or usage patterns when incorporating these ingredients into your routine.

It’s best to use niacinamide one day and vitamin C the next, giving your skin time to adjust without overloading it with active ingredients.

Most importantly, listen to your skin and adjust your skincare routine accordingly. If you notice any signs of irritation or sensitivity, scale back on the frequency of use or try applying the products to different areas of your face to see how your skin reacts.

Possible Side Effects and How to Address Them

While niacinamide and vitamin C are generally well-tolerated by most skin types, some individuals may experience mild side effects, especially when first introducing these ingredients into their routine.

Common side effects include:

  • Tingling or Stinging Sensation: This sensation may occur, particularly with vitamin C serums, due to the low pH. If the sensation is mild, it’s usually normal and should subside quickly.

However, if it persists or becomes uncomfortable, consider using it less frequently.

  • Redness or Irritation: Some individuals may experience redness or irritation, especially with higher concentrations of vitamin C. If this occurs, reduce the frequency of use or opt for a lower-concentration formula.

Additionally, consider patch-testing new products before applying them to your entire face to assess tolerance.

  • Dryness or Flakiness: Both niacinamide and vitamin C can have drying effects, particularly if used in high concentrations or combined with other active ingredients like retinoids.

Ensure you’re hydrating your skin adequately with a moisturiser to counteract any potential dryness.



If you experience persistent or severe side effects, discontinue use and consult an esthetician for personalised advice.

Ensure that you pick the right product for your skin type. When in doubt, consult an experienced skincare professional.

Final Thoughts

 In conclusion, both ingredients offer significant benefits: niacinamide enhances the skin barrier and reduces inflammation, while vitamin C brightens the complexion and boosts collagen production.

For optimal results, it’s advisable to apply them in a structured routine—using vitamin C in the morning and niacinamide at night. Individuals with sensitive skin may benefit from alternating their use to minimize irritation.

Ultimately, understanding your skin’s needs and consulting with a skin care professional can help you incorporate these powerful ingredients safely into your regimen.

FAQs:  How To Use Niacinamide and Vitamin C

Is it better to use niacinamide in the morning or at night?

Niacinamide is versatile and can be used at any time of the day, but it is often recommended for morning application. The key consideration is how it fits into your overall skincare routine.

For example, if you are using vitamin C, it is best to apply vitamin C in the morning to take advantage of its brightening and protective properties, while reserving niacinamide for nighttime use. This approach not only maximizes the benefits of both ingredients but also helps minimize potential irritation.

What should you not use with niacinamide?

We recommend not using niacinamide with glycolic acid due to their differing pH levels, which can lead to reduced effectiveness. Additionally, while some sources suggest that niacinamide can be used with vitamin C, we recommend applying them at different times of day to prevent potential irritation

Does niacinamide brighten skin?

Yes, niacinamide can help brighten the skin. It reduces hyperpigmentation and evens out skin tone, leading to a healthier and more radiant complexion over time

What works well with niacinamide?

Niacinamide pairs well with hyaluronic acid. It also pairs well with a variety of ingredients like retinol, and peptides. These combinations can enhance hydration, improve skin texture, and provide anti-ageing benefits without causing irritation

Can I use niacinamide with vitamin C every day?

Yes, you can use niacinamide and vitamin C every day. However, if you have sensitive skin, we recommend using it every other day. 

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